Physiologic Hemoglobin Scavengers And Detoxification Systems Hb Can Be Physiologic hemoglobin scavengers and detoxification systems. hb can be released from red blood cells (rbc) into the plasma and extracellular environment during hemolysis or tissue injury. in the extracellular compartment, hb reacts with peroxides (h 2 o 2 and lipid hydroperoxides) and promotes oxidative tissue damage. Physiologic hemoglobin scavengers and detoxification systems. hb can be released from red blood cells (rbc) into the plasma and extracellular environment during hemolysis or tissue injury.
Summary Of Intravascular Extravascular Hb Heme Clearance And An efficient clearance system comprising macrophages and scavenger proteins maintains homeostasis within the red blood cell (rbc) compartment, 1 by capturing aged and damaged rbcs, shuttling heme iron to erythropoiesis, and preventing the adverse effects of cell free hemoglobin (hb) and heme. Introduction. when hemoglobin (hb) bursts from rbcs because of hemolysis, the naked hb, devoid of its antioxidant sentries that are normally available within the rbc, can wreak oxidative havoc in the vasculature and in exposed tissues. 1 to neutralize hb and its reactive ferric protoporphyrin ix group (hemin), specialized plasma scavenger proteins sequester the toxic moieties and transit them. Physiologic hemoglobin scavengers and detoxification systems. hb can be released from red blood cells (rbc) into the plasma and extracellular environment during hemolysis or tissue injury. Emerging insights into hemoglobin (hb) toxicity as well as physiologic hb scavengers such as haptoglobin and cd163 that are capable of detoxifying extracellular hb in vivo suggest that alternative product candidates could be designed. together with novel animal models and biomarkers tailored to monitor the effects of extracellular hb, a new.
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