Immunohistochemical Detection Of Cc10 Positive Cells In The Lungs Of

Immunohistochemical Detection Of Cc10 Positive Cells In The Lungs Of Immunohistochemical detection of cc10 positive cells in the lungs of cc10k18 mlacz transgenic mice. (a) x gal staining showing the expression of the lacz reporter gene by the human cc10 promoter and k18 m in a day 8 postnatal transgenic mouse (arrow points to positive x gal staining cells). (b) cc10 immunostaining of a tissue section of the. Allergic asthma is a complex inflammatory disorder predominantly orchestrated by t helper 2 (th2) lymphocytes. the anti inflammatory protein clara cell 10 kda (cc10), also known as secretoglobin family 1a member 1 (scgb1a1), shows promise in modulating respiratory diseases. however, its precise role in asthma remains unclear. this study examines the potential of cc10 to suppress allergic.

Immunohistochemical Detection Of Cc10 Positive Cells In The Lungs Of A Clara cell 10 kda protein (cc10) uteroglobin (ug) is a nonglycoprotein with a molecular mass of 16 kilodaltons, which is produced by mucosal epithelial cells in the lung (clara cells), uterus and. Clara cell 10 kda protein (cc10) is the major secretory protein of clara cells and is thought to play a protective role in the lung owing to its anti inflammatory properties. there is little information on the anatomical distribution of cc10 positive cells in rat lung following lipopolysaccharide (lps) challenge. Immunohistochemical staining with anti cc10 antibody shows expression in the majority of airway epithelial cells of the wild type mouse lung (b), whereas the cc10 knockout mouse airways lack. Double immunohistochemical staining for cc10 and sp a revealed that the cc10 positive cells lining both the bronchi and bronchioles were different from the sp a positive cells. this finding suggests that cc10 positive cells are functionally and developmentally heterogeneous in both fetal and neonatal lungs in humans.