How Do Helper T Cells Activate B Cells Pediaa Com 9 5. antigen binding b cells are trapped in the t cell zone of secondary lymphoid tissues and are activated by encounter with armed helper t cells. one of the most puzzling features of the antibody response is how an antigenspecific b cell manages to encounter a helper t cell with an appropriate antigen specificity. At the follicle t zone interface, b cells interact with cd4 helper t cells, the latter often (but not always) pre activated by encounter with antigen presenting dendritic cells (dcs), and they engage in interactions that last 10’s of minutes and sometimes more than an hour (allen et al., 2007; hong et al., 2018; qi et al., 2014).
What Are Helper T Cells Vrogue Co The peptide class ii mhc complexes are then recognized by effector helper t cells, which can now deliver signal 2. signal 1 prepares the b cell for its interaction with a helper t cell by increasing the expression of both class ii mhc proteins and receptors for signal 2. The resulting b cell−t cell interactions result in both t cell activation, through mhc restricted antigen presentation, and contact mediated b cell activation. the study showed that b cells. Some cd4 t cells are differentiated into t follicular helper (t fh) cells, which engage in critical interactions with b cells in germinal center, resulting in the production of high affinity. A t dependent b cell response involves germinal centers (gcs), in which antigen activated b cells proliferate, hypermutate, and undergo affinity based selection by follicular t helper (t fh) cells.
Comments are closed.